QuarkXPress freezes up as soon as the splash screen appears
This only occurs on the QuarkXPress 4.x versions that use a hardware dongle.
A bug in the QuarkXPress code that verifies that you do not have a pirated copy of QuarkXPress on your network causes QuarkXPress to fail to find the hardware dongle. If you leave QuarkXPress alone for 4-5 minutes, you will see a message telling you that QuarkXPress cannot find the license manager. You will then be able to close QuarkXPress normally.
When this happens, the only way to have QuarkXPress allow you to run it again is to restart your computer.