Currently (October 2021), the XV4 64-bit version of Q++Studio supports QuarkXPress versions, from QuarkXPress 8 to QuarkXPress 2021, inclusively.
However, not all versions of QuarkXPress are supported by all versions of Windows, and vice-versa.
Quark-Windows Restrictions and Incompatibilities
•QuarkXPress 8 can only run on Windows 7 (not on Windows 10).
•QuarkXPress 2019-2020-2021 can only run on Windows 10.